Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers
Identifieur interne : 000838 ( Main/Exploration ); précédent : 000837; suivant : 000839Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers
Auteurs : Xiaomei Yang ; Jing Zhao ; Siliang Duan ; Xiaoqiong Hou ; Xi Li ; Zixi Hu ; Zhuoran Tang ; Fengzhen Mo ; Xiaoling LuSource :
- Theranostics [ 1838-7640 ] ; 2019.
Abstract
Url:
DOI: 10.7150/thno.33383
PubMed: 31281532
PubMed Central: 6592167
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers</title><author><name sortKey="Yang, Xiaomei" sort="Yang, Xiaomei" uniqKey="Yang X" first="Xiaomei" last="Yang">Xiaomei Yang</name></author><author><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></author><author><name sortKey="Duan, Siliang" sort="Duan, Siliang" uniqKey="Duan S" first="Siliang" last="Duan">Siliang Duan</name></author><author><name sortKey="Hou, Xiaoqiong" sort="Hou, Xiaoqiong" uniqKey="Hou X" first="Xiaoqiong" last="Hou">Xiaoqiong Hou</name></author><author><name sortKey="Li, Xi" sort="Li, Xi" uniqKey="Li X" first="Xi" last="Li">Xi Li</name></author><author><name sortKey="Hu, Zixi" sort="Hu, Zixi" uniqKey="Hu Z" first="Zixi" last="Hu">Zixi Hu</name></author><author><name sortKey="Tang, Zhuoran" sort="Tang, Zhuoran" uniqKey="Tang Z" first="Zhuoran" last="Tang">Zhuoran Tang</name></author><author><name sortKey="Mo, Fengzhen" sort="Mo, Fengzhen" uniqKey="Mo F" first="Fengzhen" last="Mo">Fengzhen Mo</name></author><author><name sortKey="Lu, Xiaoling" sort="Lu, Xiaoling" uniqKey="Lu X" first="Xiaoling" last="Lu">Xiaoling Lu</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31281532</idno><idno type="pmc">6592167</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6592167</idno><idno type="RBID">PMC:6592167</idno><idno type="doi">10.7150/thno.33383</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000817</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000817</idno><idno type="wicri:Area/Pmc/Curation">000817</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000817</idno><idno type="wicri:Area/Pmc/Checkpoint">000779</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000779</idno><idno type="wicri:Area/Ncbi/Merge">000777</idno><idno type="wicri:Area/Ncbi/Curation">000777</idno><idno type="wicri:Area/Ncbi/Checkpoint">000777</idno><idno type="wicri:Area/Main/Merge">000838</idno><idno type="wicri:Area/Main/Curation">000838</idno><idno type="wicri:Area/Main/Exploration">000838</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Enhanced cytotoxic T lymphocytes recruitment targeting tumor vasculatures by endoglin aptamer and IP-10 plasmid presenting liposome-based nanocarriers</title><author><name sortKey="Yang, Xiaomei" sort="Yang, Xiaomei" uniqKey="Yang X" first="Xiaomei" last="Yang">Xiaomei Yang</name></author><author><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></author><author><name sortKey="Duan, Siliang" sort="Duan, Siliang" uniqKey="Duan S" first="Siliang" last="Duan">Siliang Duan</name></author><author><name sortKey="Hou, Xiaoqiong" sort="Hou, Xiaoqiong" uniqKey="Hou X" first="Xiaoqiong" last="Hou">Xiaoqiong Hou</name></author><author><name sortKey="Li, Xi" sort="Li, Xi" uniqKey="Li X" first="Xi" last="Li">Xi Li</name></author><author><name sortKey="Hu, Zixi" sort="Hu, Zixi" uniqKey="Hu Z" first="Zixi" last="Hu">Zixi Hu</name></author><author><name sortKey="Tang, Zhuoran" sort="Tang, Zhuoran" uniqKey="Tang Z" first="Zhuoran" last="Tang">Zhuoran Tang</name></author><author><name sortKey="Mo, Fengzhen" sort="Mo, Fengzhen" uniqKey="Mo F" first="Fengzhen" last="Mo">Fengzhen Mo</name></author><author><name sortKey="Lu, Xiaoling" sort="Lu, Xiaoling" uniqKey="Lu X" first="Xiaoling" last="Lu">Xiaoling Lu</name></author></analytic><series><title level="j">Theranostics</title><idno type="eISSN">1838-7640</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Background</bold>: Adequate recruitment of highly active tumor antigen-specific cytotoxic T lymphocytes (CTLs) remains a major challenge in cancer immunotherapy.</p><p><bold>Objective</bold>: To construct liposome (LP)-based nanocapsules with surface endoglin aptamer (ENG-Apt) encapsulating mouse interferon-inducible protein-10 (mIP-10), with the ability to target mouse tumor vascular endothelial cells (mTECs) and enhance CTLs targeting and recruitment to the tumor vasculature.</p><p><bold>Methods</bold>: ENG-Apt/mIP-10-LP nanocapsules were prepared by grafting DSPE-PEG<sub>2000</sub>-ENG-Apt on the surface of liposomes containing mIP-10 plasmids, characterized and assessed for the cell binding specificity<italic> in vitro</italic>. The tumor-targeting ability of ENG-Apt/mIP-10-LP nanocapsules was evaluated<italic> in vivo</italic>. The anti-tumor efficacy of ENG-Apt/mIP-10-LP nanocapsules treatment, as well as the combination treatment of ENG-Apt/mIP-10-LP nanocapsules and adoptive TRP2CD8<sup>+</sup> T cells, were both tested in melanoma-bearing mice, by evaluation of the tumor volume and the mouse survival time. To discuss the anti-tumoral mechanism of ENG-Apt/mIP-10-LP nanocapsules-based therapies, IFN-γ secretion, proportion of TRP2CD8<sup>+</sup> T cells among TILs, MDSCs in the tumor microenvironment and Tregs in the spleen, were determined after the treatments. Proliferation and apoptosis of tumor cells, and tumor angiogenesis were also assessed.</p><p><bold>Results</bold>: The prepared ENG-Apt/mIP-10-LP nanocapsules possess an adequate nanometric size, good stability, high specificity to mTECs and tumor sites, along with the ability to induce mIP-10 expression <italic>in vitro</italic> and<italic> in vivo</italic>. Treatment of ENG-Apt/mIP-10-LP nanocapsules demonstrated CTLs enrichment into the tumor site, which inhibited tumor cell proliferation and angiogenesis, as well as promoted tumor-cell apoptosis, leading to a decrease in tumor progression and prolonged survival time in melanoma tumor-bearing mice. In addition, the proportion of MDSCs and Tregs was found to decrease. The combination of ENG-Apt/mIP-10-LP nanocapsules with adoptive TRP2CD8<sup>+</sup> T cells, showed stronger abilities in inhibiting tumor growth and increasing animal survival time, thereby displayed an enhanced anti-melanoma tumor efficacy, due to the recruitment of both endogenous CD8<sup>+</sup> T cells and exogenous TRP2CD8<sup>+</sup> T cells <italic>in vivo</italic>.</p><p><bold>Conclusion</bold>: ENG-Apt/mIP-10-LP nanocapsules could enhance the recruitment of both endogenous and exogenous CTLs specifically targeting melanoma tumor vasculatures and exert anti-tumoral effect, therefore provides a potentially novel strategy for tumor immunotherapy.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Koning, D" uniqKey="Koning D">D Koning</name></author><author><name sortKey="Costa, Ai" uniqKey="Costa A">AI Costa</name></author><author><name sortKey="Hasrat, R" uniqKey="Hasrat R">R Hasrat</name></author><author><name 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sortKey="Sugiura, S" uniqKey="Sugiura S">S Sugiura</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Duan, Siliang" sort="Duan, Siliang" uniqKey="Duan S" first="Siliang" last="Duan">Siliang Duan</name><name sortKey="Hou, Xiaoqiong" sort="Hou, Xiaoqiong" uniqKey="Hou X" first="Xiaoqiong" last="Hou">Xiaoqiong Hou</name><name sortKey="Hu, Zixi" sort="Hu, Zixi" uniqKey="Hu Z" first="Zixi" last="Hu">Zixi Hu</name><name sortKey="Li, Xi" sort="Li, Xi" uniqKey="Li X" first="Xi" last="Li">Xi Li</name><name sortKey="Lu, Xiaoling" sort="Lu, Xiaoling" uniqKey="Lu X" first="Xiaoling" last="Lu">Xiaoling Lu</name><name sortKey="Mo, Fengzhen" sort="Mo, Fengzhen" uniqKey="Mo F" first="Fengzhen" last="Mo">Fengzhen Mo</name><name sortKey="Tang, Zhuoran" sort="Tang, Zhuoran" uniqKey="Tang Z" first="Zhuoran" last="Tang">Zhuoran Tang</name><name sortKey="Yang, Xiaomei" sort="Yang, Xiaomei" uniqKey="Yang X" first="Xiaomei" last="Yang">Xiaomei Yang</name><name sortKey="Zhao, Jing" sort="Zhao, Jing" uniqKey="Zhao J" first="Jing" last="Zhao">Jing Zhao</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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